FerriScan® provides an accurate measurement of liver iron concentration (LIC) through a non-invasive, MRI-based technology. The measurement is performed in a central Service Centre and provided via our unique Quality Assured Service Delivery model.


The FerriScan process uses patented R2-MRI imaging technology. Acquired magnetic resonance images are securely transmitted to the Resonance Health Service Centre. The patented FerriScan analysis procedure produces a mean LIC measurement and a colour coded map reflecting the iron distribution across the liver.

FerriScan analysis provides proven accuracy in the determination of liver iron concentration and has the highest sensitivity and specificity over the range of liver iron concentrations of any MRI-based method of LIC measurement. Results that are reliable and reproducible over time and across different models of MRI scanner.

FerriScan was originally calibrated against liver biopsy in 105 patients with various iron overload conditions. A further multi-centre validation study on five different scanners with 233 patients concluded:

  • The FerriScan technique is robust
  • There is no shift in accuracy or precision across different MRI scanners
  • FerriScan is unaffected by fibrosis or chelation therapy
  • FerriScan can be used with patients of all ages

FerriScan is recommended in multiple clinical patient management guidelines. More recently, iron overload is becoming increasing recognised as a complication in cancer survivors who received multiple blood transfusions as part of their cancer therapy. To read more about the application of FerriScan in this setting please refer here: Iron Overload in Cancer Survivors.

Key FerriScan Features

  • FerriScan provides an accurate, validated MRI-based measurement of liver iron concentration
  • FerriScan is non-invasive, requires no contrast agents and has a scan time of approximately 10 minutes
  • FerriScan has high sensitivity and specificity for measuring LIC
  • Image analysis and LIC reporting is performed at a central ISO 13485 certified Service Centre
  • FerriScan has international regulatory clearance and approvals (USA, Europe, Australia)
  • Results are available within a target time of two business days
  • FerriScan can measure LIC over the entire range encountered in clinical practice
  • FerriScan results are clinically validated to be unaffected by inflammation, fibrosis or cirrhosis
  • FerriScan requires no breath-hold and may therefore be used for paediatric patients
  • Results are accurate, reliable and reproducible over time and between MRI centres and models of scanner
  • There is no requirement for customers to purchase new software or hardware, resulting in minimal training requirements
  • FerriScan is suitable for 1.5 Tesla MRI scanners
  • FerriScan is charged per scan only

From a Clinician’s Perspective

Dr Josu de la Fuente, Consultant Paediatric Haematologist and Senior Lecturer at Imperial College London and Director of the Paediatric Blood and Marrow Transplant Programme, speaks about the clinical benefits of FerriScan:

FerriScan is included in the routine treatment protocols for Thalassaemia at the Imperial College Healthcare. For example, information about Thalassemia and evidence for the use of FerriScan in paediatric management is included in the following protocol:


Why Use FerriScan R2-MRI to Measure Liver Iron Concentration?

FerriScan is quick, easy and painless, with an MRI scan time of only ten minutes. FerriScan does not require any contrast agents and being MRI based there is no risk from radiation.

The accurate Liver iron Concentration (LIC) measurement can be used by clinicians to monitor iron loading and adjust treatment regimes accordingly.

FerriScan provides a more accurate and reliable measure of LIC at any point in time than that provided by serum ferritin and patients need no longer undergo the painful, time consuming process of liver biopsy.

Unlike liver biopsy, which provides an analysis of LIC in only one small area, FerriScan analyses a cross-section of the liver. This area is typically thousands of times larger than biopsy, hence significantly reducing the biopsy sampling error.

The analysis of data by trained experts within a quality-controlled environment eliminates issues of inter-observer variability.


If you wish to use the FerriScan service or would like to know more about FerriScan, please email .